cimetidine sulfoxide

Name	CIMETIDINE SULPHOXIDE DIHYDROCHLORIDE
Synonyms	SKF-92452 Cimetidine S-oxide cimetidine sulfoxide CIMETIDINE SULPHOXIDE DIHYDROCHLORIDE 1-cyano-2-methyl-3-[2-[(5-methyl-1H-imidazol-4-yl)methylsulfinyl]ethyl]guanidine 1-[2-[(5-Methyl-1H-imidazole-4-yl)methylsulfinyl]ethyl]-3-methyl-2-cyanoguanidine 2-Cyano-1-methyl-3-[2-[[(5-methyl-1H-imidazol-4-yl)methyl]sulfinyl]ethyl]guanidine 1-Cyano-3-methyl-2-[2-[[(5-methyl-1H-imidazole-4-yl)methyl]sulfinyl]ethyl]guanidine
CAS	54237-72-8

Molecular Formula	C10H16N6OS
Molar Mass	268.34
Density	1.39±0.1 g/cm3(Predicted)
Melting Point	>180°C (dec.)
Boling Point	594.8±60.0 °C(Predicted)
Solubility	DMSO (Slightly, Heated), Methanol (Slightly)
Appearance	Solid
Color	White to Off-White
pKa	13.38±0.10(Predicted)
Storage Condition	-20°C Freezer
In vitro study	Active transport of Cimetidine across the rat small intestine is observable at lower substrate concentrations (40 and 200 μM), but is masked by passive transfer at higher concentrations (400 μM). Cimetidine sulfoxide is detected after some incubations.
In vivo study	The enantiomeric composition of Cimetidine sulfoxide is also determined in rat urine (24 h) following the administration of Cimetidine (30 mg/kg; po) to male Wistar rats. The enantiomeric ratio in this case is found to be (+/−) 57:43.

biological activity	Cimetidine sulfoxide is a sulfoxide metabolite of Cimetidine. Cimetidine is a histamine H2 receptor (H2-receptor) antagonist that is useful in the study of peptic ulcers and upper gastrointestinal bleeding.
Target	Histamine H 2 -receptor

Last Update：2024-04-09 19:05:16